Fri Dec 12 2025

91 articles - From Friday Dec 05 2025 to Friday Dec 12 2025

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Guidelines

Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…

Am J Gastroenterol
Evaluating the 2023 EASL guidelines for intrahepatic cholestasis of pregnancy: risk stratification and outcomes in over 4,000 U.S. patients.

Our systematic evaluation of the 2023 EASL guidelines for suspected ICP demonstrated that this novel group-based classification offers clinically meaningful risk stratification. Our findings support that both elevated TSBA (Group C) and elevated ALT/AST alone (Group B) warrant antepartum surveillance for adverse pregnancy outcomes. Group C's association with Hispanic ethnicity and pre-existing liver disease highlights the need for individualized monitoring during pregnancy. Group-specific increased incidence of post-pregnancy hepatobiliary disease emphasizes the importance of targeted postpartum follow-up.

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Clin Gastroenterol Hepatol
Expert Delphi consensus on surrogate endpoints for treatment assessment in metabolic dysfunction-associated steatohepatitis.

This international Delphi study highlights histological and NIT-based measures as key for MASH treatment evaluation. It also supports a shift toward NITs-particularly LSM by VCTE or MRE-for disease monitoring in routine practice, with implications for trial design, reimbursement, and clinical guidelines.

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Endoscopy
Curriculum for safe and effective use of artificial intelligence in endoscopy: European Society of Gastrointestinal Endoscopy (ESGE) Position Statement.

The proposed framework defines the prerequisites in the preadoption phase, core training components, and requirements to maintain optimal implementation. Key recommendations include: (1) ensuring basic competency in standard endoscopy procedures; (2) acquiring foundational knowledge of AI principles; (3) implementing educational programs to enhance AI literacy; (4) recognizing and mitigating cognitive biases in human-AI interaction; (5) avoiding over-reliance on AI in clinical decision-making; and (6) continuous monitoring of key performance indicators throughout AI system integration.

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Hepatology
Updated AASLD Guidelines for Chronic Hepatitis B Treatment.

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Meta-analysis

meta-analyses and systematic reviews


Original articles

RCT, clinical trials, retrospective studies, etc…

Aliment Pharmacol Ther
Post-Banding Ulcer Bleeding After Endoscopic Ligation: Incidence, Risk Factors and Outcomes in Patients With Cirrhosis.

Patients with cirrhosis undergoing urgent EBL or those with elevated creatinine levels are at increased risk of PBUB. Due to the high mortality associated with PBUB, identifying high-risk patients and implementing preventive strategies is essential for improving patient outcomes.

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Serum Villin-1-A Novel Marker of Gut Barrier Damage in Acutely Decompensated Cirrhosis: A Cohort Study and Validation.

Serum VIL1 is a non-invasive indicator of gut barrier damage and short-term mortality in AD cirrhosis. Incorporating VIL1 assessment into risk stratification methods improves prognostic accuracy by capturing an essential, yet previously overlooked component of disease progression.

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Am J Gastroenterol
An EREFS threshold of 2 or less is robust for assessing endoscopic response to treatment of eosinophilic esophagitis.

Post-treatment EREFS≤2 was consistent with symptom and histologic response for the entire cohort. These data support EREFS≤2 as a robust threshold to define endoscopic response.

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Effectiveness and tolerability of bezafibrate in primary biliary cholangitis - a nationwide real-world study.

In this real-world nationwide study, the one-year fibrate discontinuation rate was substantial. However off-label use of bezafibrate was associated with reductions in the biochemical markers of cholestasis in PBC, which were associated with clinical outcome in this setting of second line therapy.

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Efficacy and safety of Auricular Acupressure for Insomnia In Patients with Functional Dyspepsia: A Randomized Controlled Trial.

Among patients with FD and insomnia, a two-week treatment of AA is more effective than SAA in improving the response rate, with benefits maintained over an 8-week follow-up period.

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Low Diastolic Blood Pressure and Risk of Ischemic Colitis in the Women's Health Initiative Cohort.

Incidence rate of IC in older women was twice as high in those with a history of cardiovascular disease and was associated with low diastolic blood pressure and multi-class antihypertensive treatment. Dietary fiber intake was associated with lower risk. Black women had lower risk of IC compared to White women.

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Use of Large Language Models to Determine the Surveillance Colonoscopy Interval: A Bi-institutional Validation Study.

LLMs with a custom prompt achieve consistently high accuracy in determining the guideline-based surveillance colonoscopy interval.

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Clin Gastroenterol Hepatol
Psychological factors: the defining features of quality of life in disorders of gut-brain interaction - a comparative exploratory analysis.

Psychological comorbidity appears the most salient factor associated with HrQoL, which was uniformly seen across different DGBI, whereas GI-symptom severity was only associated with HrQoL in FD and patients with IBS, but not in patients with FI. Although causality between psychological factors and HrQoL cannot be ascertained, our findings underscore the importance of holistic DGBI-management that extends beyond symptom-control to encompass the full spectrum of patient-experience.

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The Cost-effectiveness of Gastric Cancer Screening and Surveillance Among Average-risk and Risk-stratified Populations.

Targeted screening in high-risk individuals for GC should be considered in the United States. Combining upper and lower endoscopy may make one-time GC screening and risk-stratified surveillance feasible for the general population. Prospective studies are needed to validate potential benefits of preventative interventions.

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Endoscopy
"Resect and pool": Surveillance interval agreement, safety, and savings from placing all colorectal polyps considered zero risk of cancer in one container for pathologic assessment.

When performed by an endoscopist with expertise in optical diagnosis, resect and pool colonoscopy was safe, permitted correct prediction of surveillance intervals, and reduced pathology charges and carbon emissions.

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Gastroenterology
An Exosome-Based Liquid Biopsy for the Detection of Early-Onset Colorectal Cancer: The ENCODER Multicenter Study.

ENCODER represents the largest EOCRC study to date to develop, train, and externally test a liquid biopsy for the growing population at risk of EOCRC, offering a complementary screening strategy. , Number NCT06342401.

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Clusterin Drives Fiber Endocytosis by Mesothelial Cells to Resolve Liver Fibrosis.

Pericentral senescent hepatocytes secrete CLU to induce the proliferation and migration of mesothelial cells to endocytose fibers by its receptor LRP2, thus reducing liver fibrosis. The engineered CLUtide mimicking CLU may be promising for resolving hepatic deposited fibers during liver fibrosis.

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Gastrointest Endosc
Optimal endoscopic treatment for rectal neuroendocrine tumors, confirmed after forceps biopsy: A Korean Association for the Study of Intestinal Diseases multicenter, randomized non-inferiority trial.

The m-EMR did not demonstrate non-inferiority to ESD for complete resection of biopsy-proven rectal NETs ≤10 mm. Thus, when both m-EMR and ESD are accessible, m-EMR may not be the preferred resection modality in patients subjected to pre-resection forceps biopsy. Further studies are needed to explore the potential role of m-EMR in resource-limited settings. (Trial number KCT0006881).

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Gut
Autophagy of Kupffer cells modulates CD8<sup>+</sup> T cell activation in primary biliary cholangitis.

Macrophage autophagy promotes autoimmune cholangitis and strongly supports this pathway as a potential therapeutic target.

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Stem-like CD8+ T cells preserve HBV-specific responses in HBV/HIV co-infection.

People with well-controlled HBV/HIV co-infection maintain robust CD8 + T cell responses with preserved stem-like properties supporting antiviral function. These results challenge assumptions about additive immune dysfunction in dual chronic infections and highlight the need for tailored immune-modulatory therapies.

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Hepatology
CXCR6 defines a distinct resident state in γδ T cells for protecting from liver cirrhosis.

Liver-resident CD69⁺CXCR6⁺ γδ T cells constitute a protective immune subset that limit fibrosis development and progression. Enhancing the function or abundance of this population may offer a promising immunotherapeutic strategy for liver cirrhosis.

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Pruritus is common in primary sclerosing cholangitis, persists over time, and its intensity is associated with disease severity.

One in 4 PSC patients experience moderate-severe pruritus, with greater symptom intensity in those with advanced disease. Our dataset is able to serve as a reference tool to aid future interventional study design, with regards anti-pruritus therapies in PSC.

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Spatiotemporal landscape of intrahepatic cholangiocarcinoma liver metastasis at the single-cell level.

We revealed the key biological mechanisms involved in the invasion and colonization phases of iCCA liver metastasis. Moreover, we provide valuable data for understanding iCCA liver metastasis and a possible avenue for the treatment of advanced iCCA.

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J Hepatol
CAR T-cell therapy induces remission in multiorgan IgG4-related disease with hepatobiliary involvement.

In this treatment-refractory case of multiorgan IgG4-RD, CD19-directed CAR T cell therapy induced durable, treatment-free remission with normalization of serum IgG4 and improvement across multiple clinical endpoints. Multimodal immune profiling indicates that CAR T cells can reset the B cell compartment and dampen pathogenic T cell and stromal interactions, supporting prospective evaluation of CAR T cell therapy in IgG4-RD.

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Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link

Aliment Pharmacol Ther
A Message From the Editors.

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AP&T: Editors' Declarations of Interest.

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Editorial: Beyond DNA Suppression: HBV RNA as a Predictor of Hepatocarcinogenesis.

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Editorial: ICG-R15 by PDD-A Simple Dynamic Tool for Refining Risk Stratification in Compensated Advanced Chronic Liver Disease.

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Editorial: MetALD and Risk of Gastrointestinal Cancer-What Can We Learn From Japan?

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Clin Gastroenterol Hepatol
How to Process News About Ultra Processed Food.

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J Hepatol
From Discovery to Therapy: The Role of HSPB1 in HBV Persistence.

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When the gut guards the liver: Microbial metabolites limit collateral damage after TACE.

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Miscellaneous

misc publications eg case reports, tools of the trade, images of the month, etc…

Am J Gastroenterol
2025 CME Information.

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2025 CME Information.

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Calendar of Courses, Symposiums and Conferences.

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Calendar of Courses, Symposiums and Conferences.

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Diffuse Papillomatosis Involving the Esophagus and Hypopharynx: A Case Report.

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Letter to the Editor.

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When Refractory Crohn's Disease Isn't Crohn's: Ileal Endometriosis.

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Clin Gastroenterol Hepatol
Melanosis Ilei and Melanosis Coli Secondary to Iron Supplementation.

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The six-food elimination diet improves symptoms of functional dyspepsia.

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Endoscopy
A novel technique for endoscopic stepwise clamping and resection of giant pedunculated colonic polyps.

Pubmed   Journal   ReadQx   PMC

Acute pancreatitis following endoscopic hemostasis of a periampullary Dieulafoy lesion: successful rescue by endoscopic retrograde cholangiopancreatography.

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An unforgettable diagnostic journey: multimodal evaluation of jejunal diverticulitis mimicking Crohn's disease.

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Band-ligation followed by anchor pronged clips for greater post-endoscopic submucosal dissection defect closure.

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Cholangioscopic evaluation of distal bile duct stones and intraductal lesions in a patient with anomalous junction of pancreaticobiliary ducts and pancreatic duct anomaly.

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Closure with a dual-action tissue clip for full-thickness defects following endoscopic submucosal dissection of a lesion involving a colonic diverticulum.

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Combined in-stent radiofrequency ablation and cholangioscopy-guided laser ablation for complex recurrent biliary obstruction.

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Endoscopic closure of a refractory post-surgical pouch by mucosal resection and suturing.

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Endoscopic full-thickness clip closure of a duodenal fistula secondary to foreign body impaction.

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Endoscopic full-thickness resection for a submucosal tumor at the esophageal entrance: is closure obligatory?

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Endoscopic ultrasound-guided choledochoduodenojejunostomy via afferent limb: a novel approach for hepaticojejunostomy stricture.

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Endoscopic ultrasound-guided portal vein marking facilitates transjugular intrahepatic portosystemic shunt for portal cavernoma.

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Endoscopic ultrasound-guided treatment of splenic artery pseudoaneurysm and pancreatic pseudocyst.

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Endoscopic vacuum-assisted closure combined with ventricular septal defect occluder for the treatment of complex anastomotic leak after esophageal cancer surgery: a case report.

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Life-threatening hemobilia following plastic stent removal in a patient with biliary anastomotic stricture after liver transplantation.

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Lumen-apposing metal stent in a right renal cyst as a complication of endoscopic ultrasound-guided gallbladder drainage.

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Novel closure technique using dual-action tissue clip with multi-bending scope for mucosal defects after gastric endoscopic submucosal dissection.

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Pre-sealing in different settings requires different modes.

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Radial laser ablation under cholangioscopic guidance for a tight intrahepatic bile duct stricture caused by primary sclerosing cholangitis.

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Risks and opportunities: cholangioscopy-assisted strategic guidewire manipulation for the management of occlusive anastomotic stricture after liver transplantation.

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Stalk-directed endoscopic submucosal dissection for a giant Brunner's gland gamartoma causing duodenal intussusception with defect closure using three-arm traction clips.

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Stepwise super minimally invasive full-thickness resection of early rectal cancer: based on the handmade rubber traction technique.

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Submucosal tunneling endoscopic septum division for Zenker's diverticulum in a patient with scoliosis and stent impaction.

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Successful pancreatic pseudocyst drainage via the endoscopic minor papilla approach using a novel drill dilator.

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Virtual reality cross-sections matched to endoscopic ultrasound for preprocedural simulation of hepaticogastrostomy.

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Gastroenterology
Enhanced trainer performance and resident learning following implementation of a Training the Colonoscopy Trainers course.

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Profiling the enteric nervous system.

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Tiptoeing in from the fatty fringes: mechanosensitive fibroblasts and Crohn's Disease.

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Gastrointest Endosc
EUS-choledochoduodenostomy in a rare case of Intraductal Papillary Mucinous Neoplasm (IPMN) associated biliary fistula.

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Endoscopic Hemostasis via Submucosal Polidocanol Injection: A New Paradigm for Hemorrhagic Radiation Proctopathy Management.

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Novel "Threading" Method for Gastric Foreign Body Removal.

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Novel Use of Rigidizing Overtube for Direct Endoscopic Necrosectomy.

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Simultaneous peroral endoscopic myotomy and submucosal tunneling endoscopic resection in one submucosal tunnel for coexisting achalasia and esophageal submucosal tumor.

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Gut
Multiomics- and artificial intelligence-powered research platforms for enhancing understanding and prediction of the cholangiocarcinoma patient journey.

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SIRT6-GLUL axis: rewiring nitrogen metabolism in intrahepatic cholangiocarcinoma.

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Hepatology
Addressing the utility of a novel score for "At-Risk" MASH in those with significant obesity.

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Letter to the Editor: Survival analysis pitfalls in MASLD: Proportional hazards, immortal time, and follow-up discrepancies.

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Letter to the Editor: Timing shapes adjuvant PD-1 efficacy after hepatectomy in HCC.

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Letter to the editor: Methodological considerations for ITH quantification and model integration.

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J Hepatol
Decoding the metabolic dialogue between hepatocytes and macrophages driving liver regeneration.

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Letters&Replies

Letters to the editors and authors’ replies

Aliment Pharmacol Ther
Editorial: ICG-R15 by PDD-A Simple Dynamic Tool for Refining Risk Stratification in Compensated Advanced Chronic Liver Disease. Authors' Reply.

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Editorial: MetALD and Risk of Gastrointestinal Cancer-What Can We Learn From Japan? Authors' Reply.

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Letter on 'Meta-Analysis: Mortality Trends and Risk Factors in Severe Alcohol-Associated Hepatitis'-Authors' Reply.

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Letter: Putting Crohn's Risk Prediction to Work in Perianal Fistula-Calibration, Thresholds, and Transport.

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Gastroenterology
Beyond Short-Term Relief: Rethinking Time Horizons in IBS Acupuncture Trials.

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Blurring the Line Between Control and Treatment: Reconsidering Sham Acupuncture in IBS Trials.

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Comment on "Efficacy of ACupuncTure in Irritable bOwel syNdrome (ACTION): A Multicenter Randomized Controlled Trial".

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Methodological Comments on "Efficacy of ACupuncTure in Irritable bOwel syNdrome (ACTION)" Study.

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Sham Limits, Narrow Benefits: Re-examining the ACTION Acupuncture Trial in IBS-D.

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Gut
Nucleos(t)ide analogue therapy for EASL immune-tolerant phase hepatitis B.

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J Hepatol
Hepatocyte-specific ablation of LONP1 disrupts liver glucose homeostasis in mice.

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